Monday, April 20, 2015

ALZHEIMER'S - Another Breakthrough

"Researchers at Duke have made breakthrough on Alzheimer's treatment" Daily KOS 4/16/2015

Duke University scientists have potentially discovered new avenues for Alzheimer's and dementia treatments.

They observed that in Alzheimer’s, immune cells that normally protect the brain instead begin to consume a vital nutrient called arginine.

By blocking this process with a drug, they were able to prevent the formation of ‘plaques’ in the brain that are characteristic of Alzheimer’s disease, and also halted memory loss in the mice.

What's more is that they were researching with a drug that has already begun human trials for cancer treatments—possibly paving the way for clinical trials in the near future.

While no technique that is tested in an animal can be guaranteed to work the same way in humans, the findings are particularly encouraging because, until now, the exact role of the immune system and arginine in Alzheimer’s was completely unknown.

The drug that was used to block the body’s immune response to arginine – known as difluoromethylornithine (DFMO) – is already being investigated in drug trials for certain types of cancer and may be suitable for testing as a potential Alzheimer’s therapy.

This follows on the heels of other recent breakthroughs in possible "plaque fighting" techniques for Alzheimer's patients.

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